MANGANESE (II) AND IRON (II) COMPLEXES OF CLOXACILLIN - SYNTHESIS, SPECTRAL STUDIES AND ANTIMICROBIAL ACTIVITIES

Abstract

 Manganese (II) and iron (II) complexes of cloxacillin (clox) were synthesized by direct combination of the reactants in methanol and characterized using elemental analysis, conductivity measurement and spectroscopic techniques. The ligand was found to behave as a bidentate ligand coordinating the metal ions through the carbonyl oxygen atom of β-lactam ring and nitrogen atom of secondary amide forming compounds with molecular formulae [Mn(clox)2Cl2].3H2O, [Fe(clox)2(H2O)2]SO4.2H2O, and [Fe(clox)2(H2O)2]. Antimicrobial activities of the synthesized complexes investigated against important bacteria and fungi strains at a concentration of 1.6 mg/mL in DMSO indicated that [Fe(clox)2(H2O)2]SO4.2H2O displayed higher antibacterial activity than the parent antibiotic ligand while the remaining two complexes were inactive against the four bacterial and two fungal strains used