Evaluation of Cardiac Biomarkers in Male Wistar Rats Exposed to Grains Treated with Chemical and Biological Pesticides

Abstract

 This study investigates the cardiotoxic effects of grains preserved with chemical (organophosphate) and biopesticides in Wistar rats, focusing on differences in Troponin I, LDH and Creatinine Kinase activity as biomarkers of neurotoxicity. Male Wistar rats were divided into control groups and groups treated with grains preserved with either chemical or biopesticides (bacterial and fungal) on rice and cowpeas. The results revealed that chemical pesticide-treated male rats exhibited significantly reduced Troponin I, LDH and CK compared to controls, indicating potential cardiotoxic effects, with the chemical pesticide rice group showing the highest increase in Troponin I (0.62 ± 0.24b), LDH (64.76 ± 10.33a). The chemical pesticide cowpea showed more significant increase in Creatinine Kinase. In contrast, biopesticide-treated groups generally exhibited increase particularly in LDH activity in the bacterial pesticide cowpea group (151.11 ± 18.03c). This finding highlights that both chemical pesticides and bio-pesticides cause significant cardiotoxicity.